Rapid Evolution of the Mitochondrial Genome in Chalcidoid Wasps (Hymenoptera: Chalcidoidea) Driven by Parasitic Lifestyles

Among the Chalcidoids, hymenopteran parasitic wasps that have diversified lifestyles, a partial mitochondrial genome has been reported only from Nasonia. This genome had many unusual features, especially a dramatic reorganization and a high rate of evolution. Comparisons based on more mitochondrial genomic data from the same superfamily were required to reveal weather these unusual features are peculiar to Nasonia or not. In the present study, we sequenced the nearly complete mitochondrial genomes from the species Philotrypesis. pilosa and Philotrypesis sp., both of which were associated with Ficus hispida. The acquired data included all of the protein-coding genes, rRNAs, and most of the tRNAs, and in P. pilosa the control region. High levels of nucleotide divergence separated the two species. A comparison of all available hymenopteran mitochondrial genomes (including a submitted partial genome from Ceratosolen solmsi) revealed that the Chalcidoids had dramatic mitochondrial gene rearrangments, involved not only the tRNAs, but also several protein-coding genes. The AT-rich control region was translocated and inverted in Philotrypesis. The mitochondrial genomes also exhibited rapid rates of evolution involving elevated nonsynonymous mutations

Static Observers in Curved Spaces and Non-inertial Frames in Minkowski Spacetime

Static observers in curved spacetimes may interpret their proper acceleration as the opposite of a local gravitational field (in the Newtonian sense). Based on this interpretation and motivated by the equivalence principle, we are led to investigate congruences of timelike curves in Minkowski spacetime whose acceleration field coincides with the acceleration field of static observers of curved spaces. The congruences give rise to non-inertial frames that are examined. Specifically we find, based on the locality principle, the embedding of simultaneity hypersurfaces adapted to the non-inertial frame in an explicit form for arbitrary acceleration fields. We also determine, from the Einstein equations, a covariant field equation that regulates the behavior of the proper acceleration of static observers in curved spacetimes. It corresponds to an exact relativistic version of the Newtonian gravitational field equation. In the specific case in which the level surfaces of the norm of the acceleration field of the static observers are maximally symmetric two-dimensional spaces, the energy-momentum tensor of the source is analyzed.Comment: 28 pages, 4 figures

A unique distant submillimeter galaxy with an X-ray-obscured radio-luminous active galactic nucleus

We present a multiwavelength study of an atypical submillimeter galaxy in the GOODS-North field, with the aim to understand its physical properties of stellar and dust emission, as well as the central AGN activity. Although it is shown that the source is likely an extremely dusty galaxy at high redshift, its exact position of submillimeter emission is unknown. With the new NOEMA interferometric imaging, we confirm that the source is a unique dusty galaxy. It has no obvious counterpart in the optical and even NIR images observed with HST at lambda~<1.4um. Photometric-redshift analyses from both stellar and dust SED suggest it to likely be at z~>4, though a lower redshift at z~>3.1 cannot be fully ruled out (at 90% confidence interval). Explaining its unusual optical-to-NIR properties requires an old stellar population (~0.67 Gyr), coexisting with a very dusty ongoing starburst component. The latter is contributing to the FIR emission, with its rest-frame UV and optical light being largely obscured along our line of sight. If the observed fluxes at the rest-frame optical/NIR wavelengths were mainly contributed by old stars, a total stellar mass of ~3.5x10^11Msun would be obtained. An X-ray spectral analysis suggests that this galaxy harbors a heavily obscured AGN with N_H=3.3x10^23 cm^-2 and an intrinsic 2-10 keV luminosity of L_X~2.6x10^44 erg/s, which places this object among distant type 2 quasars. The radio emission of the source is extremely bright, which is an order of magnitude higher than the star-formation-powered emission, making it one of the most distant radio-luminous dusty galaxies. The combined characteristics of the galaxy suggest that the source appears to have been caught in a rare but critical transition stage in the evolution of submillimeter galaxies, where we are witnessing the birth of a young AGN and possibly the earliest stage of its jet formation and feedback.Comment: 13 pages in printer format, 10 figures, 1 table, accepted for publication in the A&

Progressive failure modelling and ductility demand of steel beam-to-column connections in fire

A numerical procedure has been developed to model the sequences of failure which can occur within steel beam-to-column connections under fire conditions. In this procedure two recent developments, a static-dynamic solution process and a general component-based connection element, have been combined within the software Vulcan in order to track the sequence of local failures of the connections which lead to structural progressive collapse in fire. In particular the procedure developed can be used to investigate the structural behaviour in fire, particularly the ductility and fracture of different parts of the steel-to-steel connections, and the influence of the connections on the progressive collapse resistance of steel frames in fire. In the component-based connection model, a connection is represented as an assembly of "bolt-rows" composed of components representing different zones of mechanical behaviour whose stiffness, strength, ductility and fracture under changing temperatures can be adequately represented for global modelling. The potential numerical instabilities induced by fractures of individual connection's components can be overcome by the use of alternate static and dynamic analyses. The transfer of data between the static and dynamic analyses allows a seamless alternation between these two procedures to take place. Accuracy and stability of the calculations can be ensured in the dynamic phase, provided that the time steps are set sufficiently small. This procedure has the capacity of tracking the sequence of local failures (fractures of connection components, detachment and motion of disengaging beams, etc.) which lead to final collapse. Following an illustrative case study of a two-bay by two-storey frame, the effect of ductility of connections on the collapse resistance of steel frames in fire is demonstrated in two case studies of a generic multi-storey frame. It is shown that the analytical process is an effective tool in tackling the numerical problems associated with the complex structural interactions and discontinuous failures which can affect a steel or composite frame in fire, potentially leading to progressive collapse. It can be seen that both tensile and compressive ductility in the connections make a contribution to the fire resistance of the beams. Preventing the detachment of steel beams in fire can be achieved by inducing greater ductility into their connections. Combined with appropriate component-based connection models, this procedure can be adopted in performance-based fire-resistant design to assess the ductility requirements of steel connections

10-qubit entanglement and parallel logic operations with a superconducting circuit

Here we report on the production and tomography of genuinely entangled Greenberger-Horne-Zeilinger states with up to 10 qubits connecting to a bus resonator in a superconducting circuit, where the resonator-mediated qubit-qubit interactions are used to controllably entangle multiple qubits and to operate on different pairs of qubits in parallel. The resulting 10-qubit density matrix is unambiguously probed, with a fidelity of $0.668 \pm 0.025$. Our results demonstrate the largest entanglement created so far in solid-state architectures, and pave the way to large-scale quantum computation.Comment: Revised version with 16 pages, 13 figures, and 2 table

Neurogenomic Evidence for a Shared Mechanism of the Antidepressant Effects of Exercise and Chronic Fluoxetine in Mice

Several different interventions improve depressed mood, including medication and environmental factors such as regular physical exercise. The molecular pathways underlying these effects are still not fully understood. In this study, we sought to identify shared mechanisms underlying antidepressant interventions. We studied three groups of mice: mice treated with a widely used antidepressant drug – fluoxetine, mice engaged in voluntary exercise, and mice living in an enriched environment. The hippocampi of treated mice were investigated at the molecular and cellular levels. Mice treated with fluoxetine and mice who exercised daily showed, not only similar antidepressant behavior, but also similar changes in gene expression and hippocampal neurons. These changes were not observed in mice with environmental enrichment. An increase in neurogenesis and dendritic spine density was observed following four weeks of fluoxetine treatment and voluntary exercise. A weighted gene co-expression network analysis revealed four different modules of co-expressed genes that were correlated with the antidepressant effect. This network analysis enabled us to identify genes involved in the molecular pathways underlying the effects of fluoxetine and exercise. The existence of both neuronal and gene expression changes common to antidepressant drug and exercise suggests a shared mechanism underlying their effect. Further studies of these findings may be used to uncover the molecular mechanisms of depression, and to identify new avenues of therapy

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain

Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system. Recent data indicate that peripheral immune stimulation can significantly affect the CNS. But the mechanisms underpinning this relationship remain unclear. The standard approach to understanding this relationship has relied on systemic immune activation using bacterial components, finding that immune mediators, such as cytokines, can have a significant effect on brain function and behaviour. More rarely have studies used disease models that are representative of human disorders. Methods: Here we use a well-characterised animal model of psoriasis-like skin inflammation—imiquimod—to investigate the effects of tissue-specific peripheral inflammation on the brain. We used full genome array, flow cytometry analysis of immune cell infiltration, doublecortin staining for neural precursor cells and a behavioural read-out exploiting natural burrowing behaviour. Results: We found that a number of genes are upregulated in the brain following treatment, amongst which is a subset of inflammatory chemokines (CCL3, CCL5, CCL9, CXCL10, CXCL13, CXCL16 and CCR5). Strikingly, this model induced the infiltration of a number of immune cell subsets into the brain parenchyma, including T cells, NK cells and myeloid cells, along with a reduction in neurogenesis and a suppression of burrowing activity. Conclusions: These findings demonstrate that cutaneous, peripheral immune stimulation is associated with significant leukocyte infiltration into the brain and suggest that chemokines may be amongst the key mediators driving this response

The X-ray emission lines in GRB afterglows: the evidence for the two-component jet model

Recently, X-ray emission lines have been observed in X-ray afterglows of several $\gamma$-ray bursts. It is a major breakthrough for understanding the nature of the progenitors. It is proposed that the X-ray emission lines can be well explained by the Geometry-Dominated models, but in these models the illuminating angle is much larger than that of the collimated jet of the $\gamma$-ray bursts(GRBs). For GRB 011211, we obtain the illuminating angle is about $\theta\sim45^{\circ}$, while the angle of GRB jet is only $3.6^{\circ}$, so we propose that the outflow of the GRBs with emission lines should have two distinct components. The wide component illuminates the reprocessing material, and produces the emission lines, while the narrow one produces the $\gamma$-ray bursts. The observations show that the energy for producing the emission lines is higher than that of the GRBs. In this case, when the wide component dominates the afterglows, a bump will appear in the GRBs afterglows. For GRB 011211, the emergence time of the bump is less than 0.05 days after the GRB, it is obviously too early for the observation to catch it. With the presence of the X-ray emission lines there should also be a bright emission component between the UV and the soft X-rays. These features can be tested by the $Swift$ satellite in the near future.Comment: 10 pags, 1 figure, ChJAA in pres